Addressing large and
growing unmet needs

Quoc Le-Nguyen is the chief technical operations officer and head of quality of 89bio. He has over 25 years of experience in biopharmaceutical operations from large pharma and small startup and has the rare experience of both starting a manufacturing operation and closing a manufacturing plant. Quoc is a seasoned executive with extensive knowledge in technical operations and product supply, including building out facilities, organization, and systems as well as advancing programs through various stages of clinical development to licensure. His most recent position was SVP, global head of technical operations & quality for Aduro BioTech, where he was responsible for clinical supply including analytical/process development, manufacturing, supply chain, and quality for all three platforms: Cell Therapy, Small Molecule, and Antibody. Prior to that, Quoc was the VP of manufacturing operations for Bayer Healthcare, responsible for the Betaferon/Betaseron franchise. Quoc also played a critical role in the startup of BioMarin, in the development and approval of their first product, Adurazyme, in 2001.

Quoc holds a BS in biochemistry from the University of California at Davis.

Ryan Martins is chief financial officer (CFO) of 89bio. He brings almost 20 years of biotech experience to the company, including having completed strategic financings and acquisitions with an aggregate transaction value in excess of $1 billion. Ryan was most recently CFO at privately held Revolution Medicines, prior to which he was vice president, head of corporate strategy and investor relations at Ultragenyx. Prior to Ultragenyx, Ryan spent nearly 10 years as a biotechnology analyst at Jefferies, Lazard, and Barclays/Lehman Brothers, where he conducted in-depth analysis of profitable, public, and private biotech companies. Ryan began his career at Chiron Corp., where he held operating roles in commercial, business development, and legal until its acquisition by Novartis for approximately $5 billion.

Ryan earned his BS in Life Sciences from St. Xavier’s College, an MS degree in Biology from Virginia Tech, and an MBA from the Haas School of Business at U.C. Berkeley.

Melissa Abel is VP, Commercial Strategy & Communications at 89bio with responsibility for commercial, medical affairs and corporate communications. She has more than 25 years of broad commercial experience in the biopharmaceutical industry. From 2016-2020, she worked as VP, Commercial Strategy at Concentric Analgesics and Five Prime Therapeutics, both companies in the pre-commercialization phase. Prior to that, she led the launch and commercialization of XTANDI® (enzalutamide), one of the most successful prostate cancer medicines ever developed, for Medivation (2009-2014). Prior to Medivation, she worked at a several pre-commercial and commercial companies including Anesiva, Telik, Alza and Chiron. She began her career in Sales and Marketing at SmithKline Beecham (1995-1999).

Melissa holds an MBA from Emory University Goizueta Business School and a BA in statistics from the University of Chicago.

Michael Baldwin is VP, Quality Assurance at 98bio. Michael has more than 25 years of experience in biotechnology including Quality Assurance (in-house and CMO/CDMO manufactured products), Global Operations, Regulatory Affairs, Clinical Operations, Tech Transfer, Manufacturing, product launch, medical devices, and establishment of quality systems. Prior to joining our company, Michael was the Director of Quality Assurance at Bayer Healthcare responsible for all aspects of quality assurance for Bayer’s Hematology products manufacturing from 2016 to 2019. He served as Bayer’s Head of Contract Manufacturing Biotech QA in Berlin from 2014 to 2016, responsible for oversight of contracted biotech products and establishment of quality teams in Berlin and Basel. He has held multiple quality roles at Bayer, Novartis and Chiron in addition to managing manufacturing and facility startup operations earlier in his career.

Michael earned his B.S. in Biology from the University of California, Davis.

Dr. Will Charlton is VP, Clinical Development at 89bio. Will is a pediatric endocrinologist who gained extensive experience in clinical development, medical affairs, and drug safety after more than 11 years in clinical practice. Will began his industry career in drug safety at Gilead Sciences, worked in medical affairs and clinical development at Versartis, and in clinical development at Ascendis Pharma and Allergan.

Will earned a medical degree from the University of Southern California, completed his pediatric residency at Children’s Hospital Los Angeles and his fellowship in Pediatric Endocrinology at the University of California, San Francisco.

Shiva Natarajan is VP Finance & Principal Accounting Officer. Shiva has over 25 years of extensive accounting and financial management experience in both public and private companies. Most recently he served as CFO of SiFive, Inc., from 2017 to 2019. Before SiFive, between 2015 and 2017, he was vice president finance at A10 Networks. Prior to A10 Networks, Shiva was vice president and chief accounting officer at Fluidigm Corporation and held several roles at Applied Micro Corporation, including vice president, chief accounting officer and interim chief financial officer. Earlier in his career he held positions of increasing responsibility at various high technology companies and worked as senior manager at Ernst & Young LLP in their Assurance and Business Advisory practice.

Shiva is a Certified Public Accountant and holds a Bachelor of Science from the University of Calcutta.

Moti Rosenstock is vice president for preclinical development at 89bio. Moti has more than 20 years of industry preclinical experience in drug development, including of small molecules and biologics from early lead selection up to NDA/BLA submission. From 2001-2018 Moti was at Teva Pharmaceuticals Ind. Ltd. and served as Director and Head of Biotechnology-derived drugs and New Therapeutic Entities (NTEs) development in the Non-Clinical Safety Dept. of the innovative R&D. During his time at Teva Moti was involved in multiple preclinical due-diligence processes and development of different drugs, including the final acquisition of Labrys and preclinical development for Ajovy (fremanezumab) for the treatment of migraine. Moti joined 89bio with the establishment of the company in 2018 and since then has expanded his scope beyond toxicology to include all aspects of preclinical development, including pharmacology and pharmacokinetics

Dr. Rosenstock holds his B.Sc., M.Sc. and Ph.D. from Ben Gurion University of the Negev, Israel and a European Registered Toxicologist (ERT) from the Hellenic branch.

Paul Shin is Vice President, Head of R&D Operations at 89bio and is responsible for Clinical Operations, Program Management, Medical Writing and Regulatory Affairs. Paul has 25+ years of experience in positions of increasing responsibility at biopharmaceutical companies and CROs including leadership roles in clinical research & operations, program management, biometrics, medical writing and other functional areas within R&D. Prior to joining 89bio, Paul served as Vice President, Global Clinical Operations at Intercept Pharmaceuticals from December 2018 to August 2020, where he was responsible for management and execution of all clinical programs globally. Before Intercept, Paul was Sr. Vice President, Global R&D Operations at Nestle Health Sciences from 2016 to 2018, and prior to that, he served as Vice President, R&D Operations at Avanir Pharmaceuticals from 2011 to 2016. Prior to Avanir Pharmaceuticals from 2005 to 2011, Paul held leadership roles within R&D at Valeant Pharmaceuticals, Spectrum Pharmaceuticals and Prometheus Therapeutics. He has a broad background in drug development with strong organizational leadership experience in building and managing high performing, global R&D teams as well as broad therapeutic experience in CNS, Endocrinology, Cardiovascular, GI, Liver and Oncology.

Paul earned his B.S. in Biomedical Sciences from the University of California, Riverside and completed a post-graduate program in Neurosciences at University of California, Irvine.

Dr. Altschuler is the managing director of Healthcare Ventures at Ziff Capital Partners, where he co-leads the firm’s efforts towards investing in and facilitating the startup and development of companies with potentially transformative technologies that emphasize cellular and molecular approaches to human disease. Dr. Altschuler developed this expertise while cofounding Spark Therapeutics to develop and commercialize the preclinical and clinical gene therapy programs advanced at the Children’s Hospital of Philadelphia (CHOP) and other institutions. Dr. Altschuler served as Spark’s board chair from its founding through its acquisition by Roche in 2019. His tenure included leading the company through a successful transition to a public company and the launch of an approved commercial product. This was the first gene therapy for an inherited disease approved by the U.S. Food and Drug Administration and European Medicines Agency.

Dr. Altschuler is the former executive vice president for Health Affairs at the University of Miami and CEO of UHealth – the University of Miami Health System. He also served as CEO for CHOP from 2000 to 2015.

Dr. Altschuler completed a pediatric internship and residency at Children’s Hospital Medical Center in Boston and completed a fellowship in gastroenterology and nutrition at CHOP. He also served as a faculty member and chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania prior to becoming CEO of CHOP.

Dr. Altschuler is a member of the board of directors of WW (formally Weight Watchers International), Orchard Therapeutics, AsclepiX Therapeutics, ImVaX inc. and Platelet Biogenesis. He is also an independent trustee of the Brigham and Women’s Physician Organization at Mass General Brigham.

Dr. Altschuler holds a BA in mathematics and an MD from Case Western Reserve University.

Derek DiRocco is a principal on the Investment Team at RA Capital Management, LLC, a multi-stage investment manager dedicated to evidence-based investing in healthcare and life sciences, including companies developing novel drugs, medical devices, and diagnostics. Derek works on both public and private investments and serves as a board director for 89Bio, Ltd. Previously, Derek covered solid tumor oncology landscapes. Derek holds a BA in Biology from Holy Cross College and a PhD in Pharmacology from the University of Washington. He conducted his postdoctoral research at Brigham and Women’s Hospital/Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Ms. Zoth has served as a member of our Board of Directors since August 2020. Ms. Zoth is a Certified Public Accountant and has served as Chief Financial Officer, Chief Accounting Officer and Controller for various publicly traded companies, including MedImmune, Inc. and PSINet, Inc., and as a financial executive in various roles and Sodexho Maririott, Marriott International, Pesi-Cola International and PepsiCo. Ms. Zoth began her career as an auditor with Ernst & Young. Ms. Zoth currently serves on the boards of Zymeworks, Inc., (Chairman, Board member and Audit Committee Chair), Lumos Pharma, Inc. (Board Member and Audit Committee Chair, Compensation Committee Member) and Inovio Pharmaceuticals, Inc. (Board Member, Audit Committee Member and Compensation Committee Member and Audit Committee Chair). Previously, Ms. Zoth served on the boards of six other biopharmaceutical companies (Aeras, Circassia Pharmaceuticals, plc., Hyperion Therapeutics, Inc., Ikaria, Inc., Orexigen Therapeutics, Inc., and Spark Therapeutics. Inc.). Ms. Zoth received a BBA in accounting, summa cum laude, from Texas Tech University.